Asymmetric Synthesis of Quaternary α- and β-Amino Acids and β-Lactams via Proline-Catalyzed Mannich Reactions with Branched Aldehyde Donors.
✍ Scribed by Naidu S. Chowdari; Jeff T. Suri; Carlos F. III Barbas
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 35 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Asymmetric Mannich Synthesis of β-Amino Acids with Two New Stereogenic Centers at the α and β Positions. -The ZnCl2-catalyzed Mannich reaction of N-galactosyl aldimines, e.g. ( I), with ketene acetals as the C-nucleophiles furnishes β-amino acid derivatives, important building blocks of natural prod