Asymmetric Mannich reactions catalyzed by proline and 4-hydroxyproline derived organocatalysts in the presence of water
✍ Scribed by Veverková, Eva; Liptáková, Lucia; Veverka, Miroslav; Šebesta, Radovan
- Book ID
- 120710609
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 481 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
## Abstract In this work, six isosteviolamino acid conjugates were designed and synthesized through simple condensation on a large scale without protecting group (__Scheme__). These amphiphilic organocatalysts mediated asymmetric three‐component __Mannich__ reactions of cyclohexanone and anilines
## Abstract A variety of amino acid‐derived water‐soluble primary‐tertiary diamines is prepared and successfully applied as organocatalyst in the aldol reaction of protected hydroxyacetone derivatives (I) and (IV) with aromatic aldehydes.