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Proliferative and migratory responses of murine microvascular endothelial cells to granulocyte-colony-stimulating factor

✍ Scribed by Elena Bocchietto; Antonella Guglielmetti; Francesca Silvagno; Giulia Taraboletti; Gian Piero Pescarmona; Alberto Mantovani; Federico Bussolino

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 810 KB
Volume: 155
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041550112

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✦ Synopsis

Microvascular murine endothelial cells lines transformed by middle T oncogene of polyoma virus maintain the biological characteristics of nontransformed microvascular endothelial cells (EC). By using cell lines originated from different anatomical districts (thymus, brain, heart, and skin), we demonstrated that rnurine granulocyte-colony-stimulating factor (G-CSF) induces proliferation of murine microvascular endothelial cells at nanomolar concentrations without any cooperation with fetal calf serum. The proliferative effect on murine cells is less than that elicited by epidermal growth factor (EGF), used as standard for this function.

C-CSF also promotes the migration of tEnd.1 endothelial cell line assayed by

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