Prolactin response to zotepine in schizophrenic patients

✍ Scribed by Koichi Otani; Tsuyoshi Kondo; Masayuki Ishida; Hiroshi Sasa; Hisashi Higuchi; Sunao Kaneko; Yutaka Fukushima

• Book ID: 102267277
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 393 KB
• Volume: 8
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470080107

✦ Synopsis

The prolactin response to an antipsychotic drug zotepine, which has both antidopaminergic and antiserotonergic effects, was studied in 24 inpatients suffering from schizophrenia. The daily dose was 100 mg in the first week, and 200 mg for the next three weeks. The mean serum concentrations of prolactin at the daily dose of 200 mg, but not 100 mg, were significantly higher than that before treatment. The A prolactin (the change from the pretreatment concentration) was significantly correlated with zotepine concentrations at each week. At low zotepine concentrations, patients with high pre-treatment prolactin concentrations showed negative d prolactin. The present study thus suggests that at high concentrations zotepine shows predominantly antidopaminergic effects, while at low concentrations its antiserotonergic effects are predominant andfor it acts as a dopamine agonist.