𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Relationship of butaperazine blood levels to plasma prolactin in chronic schizophrenic patients

✍ Scribed by Robert C. Smith; Carol A. Tamminga; John W. Crayton; Haroutune Dekirmenjian; John M. Davis

Book ID
104771577
Publisher
Springer
Year
1979
Tongue
English
Weight
464 KB
Volume
66
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.

πŸ“œ SIMILAR VOLUMES

Serum and cerebrospinal fluid levels of
Serum and cerebrospinal fluid levels of fluphenazine–relationship to treatment response in schizophrenic patients
✍ Ranan RimΓ³n; Reima Kampman; Raili Laru-Sompa; D. H. Wiles πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 389 KB

Serum and cerebrospinal fluid (CSF) concentrations of fluphenazine (FPZ) were measured during nine weeks of FPZ medication in 28 patients with acute symptoms of schizophrenia. A significant correlation was found between the serum and CSF FPZ values (r = 0.70, p < 0-001) throughout the entire study.