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Serum and cerebrospinal fluid levels of fluphenazine–relationship to treatment response in schizophrenic patients

✍ Scribed by Ranan Rimón; Reima Kampman; Raili Laru-Sompa; D. H. Wiles

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
389 KB
Volume
1
Category
Article
ISSN
0885-6222

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✦ Synopsis

Serum and cerebrospinal fluid (CSF) concentrations of fluphenazine (FPZ) were measured during nine weeks of FPZ medication in 28 patients with acute symptoms of schizophrenia. A significant correlation was found between the serum and CSF FPZ values (r = 0.70, p < 0-001) throughout the entire study. Patients exhibiting marked clinical improvement (MCI) had higher levels of serum and CSF FPZ than did patients showing only slight clinical improvement (SCI) or those with no treatment response (NTR). The differences between the MCI and the NTR group were at most observation points statistically significant Cp < 0-05). The figures of the SCI group formed an intermediate curve between the serum and CSF FPZ curve of the MCI and the NTR patients.

The serum and the CSF levels of FPZ were not significantly related to such variables as age, sex, duration of illness, number of previous psychotic episodes, or subtype of schizophrenia.

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