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Prolactin response to nemonapride, a new antipsychotic drug, in schizophrenic patients

โœ Scribed by K. Otani; T. Kondo; N. Yasui; A. Suzuki; H. Furukori; S. Kaneko; T. Ohkubo; T. Nagasaki; K. Sugawara; K. Hayashi

Book ID
101280417
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
89 KB
Volume
12
Category
Article
ISSN
0885-6222

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โœฆ Synopsis

The prolactin response to nemonapride, a new antipsychotic drug, was studied in 27 schizophrenic inpatients (12 males, 15 females). The daily dose of nemonapride was 18 mg/day, and the duration of treatment was 3 weeks. Plasma prolactin concentrations were measured by enzyme immunoassay. Nemonapride treatment signiยฎcantly ( p 0ร01) increased prolactin concentrations at each week in both genders. The Dprolactin (the mean concentration during 3 weeks minus the pretreatment concentration) was signiยฎcantly ( p 0ร01) greater in females (mean + SDY 81ร6 + 57ร8 ngaml) than males (34ร9 + 19ร8 ngaml). The present study thus shows that nemonapride treatment markedly increases prolactin concentrations in schizophrenic patients, with greater responses in females than males, suggesting a strong D2 receptor blockade property of the drug.

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