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Programmed induction of DNA double strand breaks during meiosis: setting up communication between DNA and the chromosome structure

✍ Scribed by Borde, Valérie; de Massy, Bernard


Book ID
120289911
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
901 KB
Volume
23
Category
Article
ISSN
0959-437X

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## Abstract Wortmannin (WM) is a potent inhibitor of the catalytic sub‐unit of DNA‐PK, which is involved in one pathway of DNA double‐strand break (DSB) rejoining, and of ATM, which functions upstream in the p53 signaling pathway. WM is known to be an efficient radiosensitizer in a variety of mamma