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The number and not the molecular structure of DNA double-strand breaks is more important for the formation of chromosomal aberrations: A hypothesis

โœ Scribed by Guenter Obe; Christian Johannes; Sylvia Ritter


Book ID
116759794
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
353 KB
Volume
701
Category
Article
ISSN
1383-5718

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โœ Angeline S. Douvas ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 731 KB

A method is described for measuring the average number of nucleaseinduced single-and double-strand breaks per DNA molecule. The procedure involves measuring the weight-average molecular weight of DNase I-digested DNA under neutral and alkaline conditions. A statistical equation is used to calculate