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Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides

✍ Scribed by E.H Vock; W.K Lutz; O Ilinskaya; S Vamvakas


Book ID
117767792
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
972 KB
Volume
441
Category
Article
ISSN
1383-5718

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## Abstract Wortmannin (WM) is a potent inhibitor of the catalytic sub‐unit of DNA‐PK, which is involved in one pathway of DNA double‐strand break (DSB) rejoining, and of ATM, which functions upstream in the p53 signaling pathway. WM is known to be an efficient radiosensitizer in a variety of mamma