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Prognostic value of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 blood levels in breast cancer

✍ Scribed by Hartog, H.; Boezen, H.M.; de Jong, M.M.; Schaapveld, M.; Wesseling, J.; van der Graaf, W.T.A.


Book ID
123328250
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
239 KB
Volume
22
Category
Article
ISSN
0960-9776

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Insulin-like growth factors (IGFs) are potent mitogens involved in the regulation of cell proliferation and apoptosis. The action of IGFs is mediated through a specific cell membrane receptor (IGF-IR), and the interactions between IGFs and this receptor are regulated by IGF-binding proteins (IGFBPs)