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Prognostic Value of Cyclin D1 and p16 in Docetaxel and Concomitant Radiotherapy for Head and Neck Squamous Cell Carcinoma

✍ Scribed by Eisaku Higuchi; Nobuhiko Oridate; Akihiro Homma; Hiroki Shirato; Yasushi Furuta; Fumiyuki Suzuki; Satoshi Fukuda


Book ID
116810833
Publisher
SAGE Publications
Year
2005
Tongue
English
Weight
48 KB
Volume
133
Category
Article
ISSN
0194-5998

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Prognostic significance of cyclin D1 and
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## Abstract ## Background The current study aimed to evaluate the significance of the cell‐cycle‐control proteins cyclin D1 and p16 as prognostic markers in head and neck squamous cell carcinoma (HNSCC) patients treated with docetaxel and radiotherapy. ## Methods Cyclin D1 and/or p16 protein exp

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## Background: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (scchn). the oncogene ccnd1 is located at 11q13 and encodes cyclin d1, a cell cycle-regulating protein. the authors investigated the clinical relevance and associations between amplifi