## Abstract ## Purpose The combination of chemotherapy and irradiation is considered the standard of care for the treatment of advanced squamous cell carcinoma of head and neck (SCCHN). Paclitaxel has shown a singleβagent activity in SCCHN. Besides, this drug is a promising radiosensitizer for som
Concomitant chemotherapy and radiotherapy for advanced squamous cell carcinoma of head and neck
β Scribed by Seung Shin Hahn; Jung-Ah Kim; William C. Constable
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 118 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0360-3016
No coin nor oath required. For personal study only.
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To determine the efficacy of adjuvant chemotherapy in patients with advanced head and neck squamous carcinoma, the National Cancer Insitute initiated a multi-institutional, prospective randomized trial termed the Head and Neck Contracts Program. Between 1978 and 1982,462 patients with resectable Sta
## Abstract Fiftyβone patients (32 previously untreated, 19 previously treated) with advanced squamous cell carcinoma of the head and neck received a single course of combination chemotherapy consisting of high dose __cis__βplatinum (DDP), bleomycin (Bleo), Β± high dose methotrexate (MTX). Thirtyβth
patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)-radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed by 5-fluorouracil (5-FU), 200 mg/m2