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Combination chemotherapy for advanced squamous cell carcinoma of the head and neck

โœ Scribed by Coker, Donald D. ;Elias, E. George ;Chretien, Paul B. ;Gray, William C. ;Coleman, John J. ;Zentai, Theresa A. ;Didolkar, Mukund S. ;Morris, Don M. ;Viravathana, Thavinsakdi ;Hebel, John R.

Publisher
Wiley (John Wiley & Sons)
Year
1981
Weight
639 KB
Volume
4
Category
Article
ISSN
0148-6403

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โœฆ Synopsis

Abstract

Fiftyโ€one patients (32 previously untreated, 19 previously treated) with advanced squamous cell carcinoma of the head and neck received a single course of combination chemotherapy consisting of high dose cisโ€platinum (DDP), bleomycin (Bleo), ยฑ high dose methotrexate (MTX). Thirtyโ€three (65%) patients responded to therapy; 5 (10%) of these patients had a complete response. Previously untreated patients and those who received the three drugs (DDP, Bleo and MTX) had the highest response rates. The duration of response was 8 to 12 weeks. Seven (15%) patients showed a twoโ€year survival rate. All nonresponders were dead of disease within two years. Three (56%) of the five completeโ€response patients and 4 (21%) of the partialโ€response patients survived for two years. The role of preoperative chemotherapy in head and neck cancer is yet to be conclusively defined.

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