The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series of 130 breast adenocarcinomas. This study intended to investigate whether the frequency of the altered expression of the tumour suppressor gene p53 and the overexpression of the oncogene c-erbB-2 in breast
β¦ LIBER β¦
Prognostic significance of serum c-erbB-2 protein in breast cancer patients
β Scribed by Peter C. Willsher; Jayne Beaver; Sarah Pinder; Jane A. Bell; Ian O. Ellis; Roger W. Blamey; John F. R. Robertson
- Publisher
- Springer US
- Year
- 1996
- Tongue
- English
- Weight
- 397 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0167-6806
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## Background: Recently, the extracellular domain of the c-erbb-2 oncogene product (her-2/neu) has been reported to be elevated in the serum of one-fourth of patients with metastatic breast carcinoma. the role of serum c-erbb-2 as a tumor marker, however, is still poorly defined. the purpose of thi