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Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus

✍ Scribed by Pradeep Bhandari; Adrian C Bateman; Raj L Mehta; Bernard SF Stacey; Penny Johnson; Ian A Cree; Federica Di Nicolantonio; Praful Patel

Book ID
115010780
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
981 KB
Volume
6
Category
Article
ISSN
1471-2407

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## Abstract ## Background Cyclooxygenase (COX)‐2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COX‐2 expression in in vitro studies. The aim of this study was to investigate COX‐2 expression and its

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## Abstract Previous studies from our laboratory and others have suggested that increased expression of __cox‐2__ is important in the genesis of esophageal adenocarcinoma. __In vitro__ studies suggest that __cox‐2__ regulates expression of the anti‐apoptotic protein bcl‐2, thus possibly accounting