Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus
✍ Scribed by Christianne J. Buskens; Bastiaan P. van Rees; Anna Sivula; Johannes B. Reitsma; Caj Haglund; Piter J. Bosma; G.Johan A. Offerhaus; J.Jan B. van Lanschot; Ari Ristimäki
- Book ID
- 119756586
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 274 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0016-5085
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## Abstract ## Background Cyclooxygenase (COX)‐2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COX‐2 expression in in vitro studies. The aim of this study was to investigate COX‐2 expression and its
## Abstract Based on our previous demonstration that elevated cyclooxygenase‐2 (COX‐2) expression is a prognostic factor for reduced survival in patients with adenocarcinoma of the esophagus, the aim of our study was to analyze the role of COX‐2 expression in esophageal squamous cell carcinoma. We