✦ LIBER ✦

Prognostic indicators for survival in head and neck squamous cell carcinomas: Analysis of a series of 621 cases

✍ Scribed by Christophe Le Tourneau; Michel Velten; Guy-Michel Jung; Guy Bronner; Henri Flesch; Christian Borel

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 131 KB
Volume: 27
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20254

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

We sought to study the influence of pt classification, pn status, tumor volume, and number of lymph nodes invaded on survival of patients with head and neck cancers to improve therapeutic indications.

Methods:

This was a retrospective study of 621 consecutive patients treated from 1990 to 1997 by a single team.

Results:

In univariate analysis, pt classification (p < .0001), pn status (p < .0001), capsule rupture (p < .0001), the number of lymph nodes invaded (0, 1-3, 4-9, > or =10) (p < .0001), and the tumor volume (p < .0001) were significantly associated with overall survival. a cox model identified as independent prognostic indicators age (p < .0001), pt classification (p < .0001), and pn status (p < .0001).

Conclusions:

Not only pt classification and pn status but also the number of the lymph nodes invaded and the tumor volume should be considered as essential prognostic indicators, and any clinical trial developed should stratify accordingly.

📜 SIMILAR VOLUMES

Cloning efficiency. A possible prognosti

Cloning efficiency. A possible prognostic indicator in squamous cell carcinoma of the head and neck

✍ Michael E. Johns; Stacey E. Mills 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB 👁 2 views

Seventy-three squamous cell carcinomas arising in the head and neck region were cultured using the soft agar clonogenic system. Thirty-six (49%) demonstrated clonal growth. The cloning efficiency was variable, ranging from 0.001 % to 1.67% (median, 0.004%). Statistically significant correlations of

Survival analysis of head and neck squam

Survival analysis of head and neck squamous cell carcinoma: Influence of smoking and drinking

✍ Farzaneh Farshadpour; Hanneke Kranenborg; Eveline Van Beeck Calkoen; Gerrit Jan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB 👁 2 views

## Abstract ## Background. Head and neck squamous cell carcinomas (HNSCCs) are associated with tobacco and alcohol; however, the prognostic relevance of these substances is unclear. ## Methods. Univariate and multivariate survival analyses were performed for patients with (__n__ = 1829) and with

Potential indicators of radiosensitivity

Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck

✍ Mary T. Sheridan; Tadgh O'Dwyer; Colin B. Seymour; Carmel E. Mothersill 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 2 views

Recently, attention has focused on the potential of oncogenes, tumour suppressor genes, and assessment of cell proliferation as biological response indicators in human cancer. In this study, immunocytochemical analysis was used to evaluate the usefulness of Ki67, epidermal growth factor receptor (EG

Prognostic value of plasminogen activato

Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma

✍ Luciënne Speleman; Jeroen D. F. Kerrebijn; Maxime P. Look; Cees A. Meeuwis; John 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB 👁 1 views

## Abstract ## Background. Tumor cell biological factors, such as urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor‐1 (PAI‐1), cathepsin D, and c‐myc play a role in tumor invasion, metastasis, and proliferation. In this study, the prognostic importance of thes

Mutational analysis of the PTEN gene in

Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma

✍ Xiyun Shao; Raj Tandon; Ghassan Samara; Hiroaki Kanki; Hiroko Yano; Lanny G. Clo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 121 KB 👁 2 views

## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci

Merkel cell carcinoma of the head and ne

Merkel cell carcinoma of the head and neck: A retrospective case series

✍ Anthony E. Brissett; Kerry D. Olsen; Jan L. Kasperbauer; Jean E. Lewis; John R. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

## Abstract ## Background. Eighty‐five percent of all Merkel cell carcinomas appear on sun‐exposed areas, with 50% to 55% occurring on the head and neck. ## Methods. A chart review was performed on 22 patients treated for Merkel cell carcinoma of the head and neck between 1981 and 1998. ## Resu