𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Survival analysis of head and neck squamous cell carcinoma: Influence of smoking and drinking

✍ Scribed by Farzaneh Farshadpour; Hanneke Kranenborg; Eveline Van Beeck Calkoen; Gerrit Jan Hordijk; Ron Koole; Piet J. Slootweg; Chris H. Terhaard

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
175 KB
Volume
33
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Head and neck squamous cell carcinomas (HNSCCs) are associated with tobacco and alcohol; however, the prognostic relevance of these substances is unclear.

Methods.

Univariate and multivariate survival analyses were performed for patients with (n = 1829) and without (n = 183) substance use.

Results.

HNSCC‐specific survival (death due to primary‐HNSCC or recurrent HNSCC) and HNSCC/second primary tumor–specific survival (death due to primary‐HNSCC or recurrent HNSCC or second primary tumor) were not significantly different for patients who smoked and drank alcohol (hazard ratio [HR], 1.26; 95% confidence interval [CI], 0.86–1.85) and those who did not (HR, 1.34; 95% CI, 0.96–1.88). Overall survival was significantly affected; HR for patients who smoked and drank alcohol was 1.50 (95% CI, 1.16–1.93).

Conclusion.

Although tobacco and alcohol use are the main risk factors for development of HNSCC, disease outcome was comparable in patients who did or did not use these substances. Tobacco and alcohol use affected overall survival, which emphasizes the importance of substance use cessation. Β© 2010 Wiley Periodicals, Inc. Head Neck, 2011

πŸ“œ SIMILAR VOLUMES

Epigenetic inactivation of the SFRP gene
Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma
✍ Carmen J. Marsit; Michael D. McClean; Constance Sloane Furniss; Karl T. Kelsey πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 French βš– 111 KB πŸ‘ 1 views

## Abstract The soluble frizzled receptor protein (__SFRP__) family encodes antagonists of the WNT pathway, and silencing of these genes, through promoter hypermethylation, leads to constitutive WNT signaling. In bladder cancers, hypermethylation of the __SFRP__ genes occurs more often in current a

Mutational analysis of the PTEN gene in
Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma
✍ Xiyun Shao; Raj Tandon; Ghassan Samara; Hiroaki Kanki; Hiroko Yano; Lanny G. Clo πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 121 KB πŸ‘ 2 views

## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci

Prognostic indicators for survival in he
Prognostic indicators for survival in head and neck squamous cell carcinomas: Analysis of a series of 621 cases
✍ Christophe Le Tourneau; Michel Velten; Guy-Michel Jung; Guy Bronner; Henri Flesc πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 131 KB πŸ‘ 1 views

## Background: We sought to study the influence of pt classification, pn status, tumor volume, and number of lymph nodes invaded on survival of patients with head and neck cancers to improve therapeutic indications. ## Methods: This was a retrospective study of 621 consecutive patients treated fr

Microsatellite analysis and response to
Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma
✍ HΓ©lΓ¨ne Blons; Arnauld Cabelguenne; FranΓ§oise Carnot; Ollivier Laccourreye; Isabe πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 144 KB πŸ‘ 2 views

Molecular studies have revealed that microsatellite instability and loss of heterozygosity occurred in head-and-neck cancer, suggesting the involvement both of suppressor and of mutator pathways in head-and-neck carcinogenesis. There is evidence for relations between tumor phenotype and clinical par

Survival of squamous cell carcinoma of t
Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis
✍ Camille C. R. Ragin; Emanuela Taioli πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 171 KB πŸ‘ 1 views

## Abstract Human papillomavirus (HPV) has been associated with head and neck squamous cell carcinomas (HNSCC), especially of the oropharynx, with highest distribution in the tonsils. HPV infection has been associated with improved outcome, although not all the studies show consistent results. The