Prognostic Implications of hMLH1 and p53 Immunohistochemical Status in Right-Sided Colon Cancer
β Scribed by Edward F. Smyth; Abhiram Sharma; Nala Sivarajasingham; John Hartley; John R. T. Monson; Lynn Cawkwell
- Book ID
- 106320365
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 165 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0012-3706
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π SIMILAR VOLUMES
The overexpression of the tumor suppressor gene p53 was investigated immunohistochemically in 144 cases of primary colorectal cancer and in 8 cases with cancer in the corresponding metastatic lymph nodes. Abnormalities in p53 expression were found in 36 cases (25%) of the 144 primary cancer cases. I
## Abstract Some studies have reported that __p53__ mutations or certain types of __p53__ mutation are associated with poor prognosis in colon cancer, while other studies have failed to show such a relationship. None of these previous studies was populationβbased. We therefore evaluated the prognos