The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series of 130 breast adenocarcinomas. This study intended to investigate whether the frequency of the altered expression of the tumour suppressor gene p53 and the overexpression of the oncogene c-erbB-2 in breast
Prognostic implication of p53 protein expression in relation to nuclear pleomorphism and the MIB-1 counts in breast cancer
β Scribed by Shinichi Tsutsui; Kazuhiro Yasuda; Hidefumi Higashi; Kouichirou Tahara; Satoshi Sugita; Hidetoshi Eguchi; Hiroto Kayashima; Nobuhiko Miyazaki; Yoichi Muto; Shoichi Era
- Publisher
- Springer Japan
- Year
- 2004
- Tongue
- English
- Weight
- 905 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1340-6868
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In the present study, TP53 alterations have been analysed and compared with the expression of the proteins p21, cyclin D1, cdk4, RB, EGFR, and MDM2 in 53 cancers of the uterine corpus. TP53 gene mutations analysed by CDGE/DGGE and direct sequencing showed a TP53 gene mutation in 18 per cent of the c