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Prognostic Criteria, Treatment and Survival in Disseminated Histiocytosis X

โœ Scribed by I. R. G. TOOGOOD; W. M. ELLIS; H. EKERT


Book ID
118705402
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
373 KB
Volume
15
Category
Article
ISSN
1034-4810

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Etoposide in the treatment of six childr
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Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.

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## Abstract Sixty children survived for five years after the diagnosis of histiocytosis X. Serious disabilities were seen in 50% of children whose disease involved soft tissue and bone. Late deaths from pulmonary failure were associated with opportunistic infections in two cases. Future treatment