A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter-4q22 is reported. A t(8;2 l)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q-and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q
Prognosis and treatment outcome in patients with acute myeloid Leukemia with t(8;21)(q22;q22)
β Scribed by Chih-Cheng Chen; Jyh-Pyng Gau; Yuan-Bin Yu; Chang-Hsien Lu; Kuan-Der Lee; Jie-Yu You
- Publisher
- Springer Healthcare Communications
- Year
- 2007
- Tongue
- English
- Weight
- 269 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0741-238X
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## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in βΌ55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5β²__RUNX1__/3β²__RUNX1T1__ fusion gene occurs in βΌ8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a