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Homozygosity for 8pter→q22 in acute myeloblastic leukemia with t(8;21)(q22;q22)

✍ Scribed by Dr. Roland Berger

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
293 KB
Volume
1
Category
Article
ISSN
1045-2257

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✦ Synopsis

A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter-4q22 is reported. A t(8;2 l)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q-and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q22-qter. This case shows that acquired hemizygosity and homozygosity do exist in leukemia as in solid malignant tumors.

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Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML
✍ Frank G. Rücker; Lars Bullinger; Alexander Gribov; Martin Sill; Richard F. Schle 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in ∼55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5′__RUNX1__/3′__RUNX1T1__ fusion gene occurs in ∼8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a