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Clinical research of biphenotypic acute leukemia with t(8;21)(q22;q22)

✍ Scribed by Guangsheng He; Ling Zhou; Depei Wu; Yongquan Xue; Mingqing Zhu; Jianying Liang; Aining Sun; Zhengming Jin; Huiying Qiu; Miao Miao; Xiaowen Tang; Zhengzheng Fu; Xiao Ma; Xiuli Wang

Publisher
Springer
Year
2007
Tongue
English
Weight
202 KB
Volume
6
Category
Article
ISSN
1610-1979

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A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter-4q22 is reported. A t(8;2 l)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q-and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q

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## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in ∼55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5β€²__RUNX1__/3β€²__RUNX1T1__ fusion gene occurs in ∼8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a