Aucubin, an iridoid glycoside was found to suppress hepatitis B virus DNA replication in vitro in a 2.2.15 cell culture system. Aucubin itself did not exhibit antiviral activity, but it showed significant activity when preincubated with β€-glucosidase. Aucubin possesses no cytotoxicity at a broad ran
Profound suppression of hepatitis B virus replication with lamivudine
β Scribed by Ching Lung Lai; Man Fung Yuen
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 191 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0146-6615
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Hepatitis B virus (HBV) reactivation has been described in cancer patients who received cytotoxic/immunosuppressive therapy and may result in liver damage of varying degrees of severity. There is no known effective treatment. Lamivudine, a nucleoside analogue, has been found to suppress HBV replicat
Lamivudine is an effective antiviral agent for the treatment of chronic type B hepatitis. Recent studies have shown the appearance of lamivudine resistant viruses with mutations at the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the viral polymerase in hepatitis B virus (HBV) infected pa
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