Production of immunoglobulin and rheumatoid factor by lymphoid cells in rheumatoid pericardium
β Scribed by David M. Spalding; Patricia Haber; Ralph E. Schrohenloher; William J. Koopman
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 400 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To determine the antiangiogenic effect of cyclosporin A (CSA) in rheumatoid arthritis (RA). ## Methods We investigated the effect of CSA on the production of vascular endothelial growth factor (VEGF) by rheumatoid synovial fibroblasts. Fibroblastβlike synoviocytes (FLS)
A clonal derivative of a transfectant of the SP2/0 myeloma cell line producing a chimeric monoclonal antibody was maintained in steady-state, continuous culture at dilution rates ranging from 0.21 to 1.04 day-'. The steady-state values for nonviable and total cell concentrations increased as the dil