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Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor α and CD40 signals

✍ Scribed by Minetake Kitagawa; Hiroshi Mitsui; Hiroshi Nakamura; Shinichi Yoshino; Shunpei Miyakawa; Naoyuki Ochiai; Makoto Onobori; Hiroshi Suzuki; Takayuki Sumida


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
202 KB
Volume
42
Category
Article
ISSN
0004-3591

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## Objective: To investigate the effects of the antiinflammatory cytokines interleukin-4 (il-4), il-10, and il-13 on tumor necrosis factor alpha (tnfalpha)-induced prostaglandin e2 (pge2) release in the cellular signaling cascade on human osteoarthritis (oa) synovial fibroblasts. ## Methods: Huma