Production of human α1proteinase inhibitor fromAspergillus niger
✍ Scribed by Liat Chill, Loc B Trinh, Elena Karnaukhova, Yakir Ophir…
- Book ID
- 120685376
- Publisher
- BioMed Central
- Year
- 2006
- Tongue
- English
- Weight
- 207 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1475-2859
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Human alpha one proteinase inhibitor (α1‐PI) was cloned and expressed in __Aspergillus niger__, filamentious fungus that can grow in defined media and can perform glycosylation. Submerged culture conditions were established using starch as carbon source, 30% dissolved oxygen concentrati
S. aureus serine proteinase inactivates human ct-l-proteinase inhibitor (a-l-PI) by attacking a single peptide bond between Ghi TM and Ala 35s giving a modified inhibitor which is a tight complex of Mr = 4,000 and 48,000 fragments. In the present paper we show that this proteolyticaUy inactivated r