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Chemoattractant activity ofStaphylococcus aureusserine proteinase modified human plasma α-1-proteinase inhibitor

✍ Scribed by Krystyna Baran; Maria Górka; Jan Potempa; Zofia Porwit-Bóbr

Book ID
104776551
Publisher
Springer Netherlands
Year
1989
Tongue
English
Weight
248 KB
Volume
56
Category
Article
ISSN
0003-6072

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✦ Synopsis

S. aureus serine proteinase inactivates human ct-l-proteinase inhibitor (a-l-PI) by attacking a single peptide bond between Ghi TM and Ala 35s giving a modified inhibitor which is a tight complex of Mr = 4,000 and 48,000 fragments. In the present paper we show that this proteolyticaUy inactivated r is a potent chemotactic factor for human neutrophiles at a nanomolar concentration, and we discuss its potential involvement in the inflammatory reaction due to S. aureus infections.

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