The production of human monoclonal antibodies for therapeutic use is of increasing importance for treatment of viral infections such as AIDS. As human x mouse heterohybridomas rarely reach the growth rates and cell specific production rates of mouse hybridomas the transfection of standard cell lines
β¦ LIBER β¦
Production of human monoclonal antibodies by heterohybridomas
β Scribed by Kazuaki Kitano; Yasushi Shintani; Yuzo Ichimori; Kyozo Tsukamoto; Seijiro Sasai; Makoto Kida
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 431 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1432-0614
No coin nor oath required. For personal study only.
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Two conceptually unique approaches are currently available for the production of human monoclonal antibodies - the 'hybridoma' technique, based on the fusion of antibody-producing B lymphocytes with plasmacytoma cells or lymphoblastoid cell lines; and the use of Epstein-Barr virus (EBV) to 'immortal
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