𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The production of monoclonal antibodies from human lymphocytes

✍ Scribed by Danuta Kozbor; John C Roder

Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
804 KB
Volume
4
Category
Article
ISSN
0167-5699

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✦ Synopsis

Two conceptually unique approaches are currently available for the production of human monoclonal antibodies - the 'hybridoma' technique, based on the fusion of antibody-producing B lymphocytes with plasmacytoma cells or lymphoblastoid cell lines; and the use of Epstein-Barr virus (EBV) to 'immortalize' antigen-specific, human B lymphocytes. Here Danuta Kozbor and, John Roder discuss the contribution each technique is making, alone or in combination, towards the desired aim of producing human monoclonal antibodies with a defined specificity.

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