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The production of monoclonal antibodies from human lymphocytes

✍ Scribed by Danuta Kozbor; John C Roder

Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
804 KB
Volume
4
Category
Article
ISSN
0167-5699

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The production of monoclonal antibodies
The production of monoclonal antibodies from human lymphocytes
✍ Danuta Kozbor; John C Roder πŸ“‚ Article πŸ“… 1983 πŸ› Elsevier Science 🌐 English βš– 804 KB

Two conceptually unique approaches are currently available for the production of human monoclonal antibodies - the 'hybridoma' technique, based on the fusion of antibody-producing B lymphocytes with plasmacytoma cells or lymphoblastoid cell lines; and the use of Epstein-Barr virus (EBV) to 'immortal

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✍ S. M. SchΓΆnmann; J. Iyer; H. Laeng; H. A. Gerber; H. KΓ€ser; K. Blaser πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 French βš– 738 KB

MAb were derived from mice immunized with cells of the human neuroblastoma line IMR-32. Five hybridomas were selected according to their selective binding to human cell lines, tumors and normal tissues. One of them, CE7, reacted with all sympatho-adrenomedullary cells (neuroblastoma, ganglioneurobla