𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Production of cytokines in patients infected by hepatitis C virus

✍ Scribed by Cribier, Bernard; Schmitt, Carine; Rey, David; Lang, Jean-Marie; Kirn, André; Stoll-Keller, Françoise

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
58 KB
Volume
55
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

T helper type 1 (Th1) cytokines play an important role in antiviral defence. The purpose of this study was to quantify by ELISA IL2, soluble receptor of IL2 (IL2Rs), IFN␥ TNF␤, IL4, IL6 and IL10 levels in the sera of 134 HCV-positive patients, 69 of whom were coinfected with HIV, and in 54 HIV-HCV-negative patients. The mean IL2Rs and IFN serum levels were much higher in patients with anti-HCV than in the control group, whereas the mean IL4 and IL6 levels were lower in patients infected with HCV. There were no significant differences in cytokine levels between patients with and without HIV. There were significantly less patients with HCV than controls with IFN ␥ levels under cut-off, and significantly more patients with HCV with IL4 levels under cut-off. Although serum level of cytokines must be interpreted with caution, the results suggest that Th1 response is enhanced in HCV infection.

📜 SIMILAR VOLUMES

Hepatitis C genotypes in patients with d
Hepatitis C genotypes in patients with dual hepatitis B and C virus infection
✍ Pontisso, P.; Gerotto, M.; Ruvoletto, M. G.; Fattovich, G.; Chemello, L.; Tismin 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 435 KB 👁 2 views

In patients with chronic hepatitis B and C virus (HBV, HCV) infection, an inverse relationship in the replicative activity of the two viruses has been reported. In the present study the genotype of HCV was evaluated in 34 consecutive cases found with hepatitis B surface antigen (HBsAg) and anti-HCV

Effect of interferon on GB virus C and h
Effect of interferon on GB virus C and hepatitis C virus in hepatitis patients with the co-infection
✍ Nagayama, Ryozo; Miyake, Kazuhiko; Okamoto, Hiroaki 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 2 views

Of 74 patients who were infected with hepatitis C virus (HCV) and received interferon, 12 (16%) were positive for RNA of GB virus C (GBV-C). RNA of GBV-C was determined in sera from the co-infected patients retrospectively, and the effect of interferon on GBV-C was compared with that on HCV in them.

Clinical significance of prior hepatitis
Clinical significance of prior hepatitis B virus infection in patients with hepatitis C virus–related hepatocellular carcinoma
✍ Shoji Kubo; Shuhei Nishiguchi; Kazuhiro Hirohashi; Hiromu Tanaka; Tadashi Tsukam 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB 👁 2 views

## BACKGROUND. The effect of prior hepatitis B virus (HBV) infection on the clinicopathologic findings for patients with hepatitis C virus (HCV) RNA and hepatocellular carcinoma (HCC) is still unclear. ## METHODS. Of 59 patients who underwent liver resection for HCV-related HCC (Յ2.0 cm in greate

Hepatitis B virus DNA is frequently foun
Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients
✍ Koike, Katsuro; Kobayashi, Midori; Gondo, Morio; Hayashi, Izumi; Osuga, Toshiaki 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 1 views

Human hepatitis B virus (HBV) and hepatitis C virus (HCV) are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). A possible involvement of HBV co-infection was investigated in ongoing HCV-related liver diseases in HCV-infec