✦ LIBER ✦

Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients

✍ Scribed by Koike, Katsuro; Kobayashi, Midori; Gondo, Morio; Hayashi, Izumi; Osuga, Toshiaki; Takada, Shinako

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 234 KB
Volume: 54
Category: Article
ISSN: 0146-6615
DOI: 10.1002/(sici)1096-9071(199804)54:4<249::aid-jmv3>3.0.co;2-4

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✦ Synopsis

Human hepatitis B virus (HBV) and hepatitis C virus (HCV) are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). A possible involvement of HBV co-infection was investigated in ongoing HCV-related liver diseases in HCV-infected patients. A prevalence of anti-HBc in anti-HCV-positive/HBsAg-negative chronic hepatitis patients and a low copy number of HBV DNA were found in most of the liver biopsy samples of anti-HCV-positive/HBsAgnegative patients. The present data suggest that HBV co-infects frequently with HCV and may play an important role in the development of HCC in the anti-HCV-positive/HBsAg-negative patients with chronic hepatitis.

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