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Clinical significance of prior hepatitis B virus infection in patients with hepatitis C virus–related hepatocellular carcinoma

✍ Scribed by Shoji Kubo; Shuhei Nishiguchi; Kazuhiro Hirohashi; Hiromu Tanaka; Tadashi Tsukamoto; Hiroyuki Hamba; Taichi Shuto; Takatsugu Yamamoto; Takashi Ikebe; Hiroaki Kinoshita

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
96 KB
Volume
86
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

The effect of prior hepatitis B virus (HBV) infection on the clinicopathologic findings for patients with hepatitis C virus (HCV) RNA and hepatocellular carcinoma (HCC) is still unclear.

METHODS.

Of 59 patients who underwent liver resection for HCV-related HCC (Յ2.0 cm in greatest dimension) without metastases between 1990 and 1997, 38 patients had anti-HB core antibody (anti-HBc) and did not have HB surface antigen in their sera (Group 1). Their clinicopathologic findings and outcomes after surgery were compared with those of the remaining 22 patients without anti-HBc (Group 2).

RESULTS. The proportion of well-differentiated HCC was significantly lower in

Group 1 than in Group 2 (P ϭ 0.0214). The percentage of patients with cirrhosis was significantly lower in Group 1 than in Group 2 (P ϭ 0.0228). The cumulative survival rate was significantly lower in Group 1 than in Group 2 (P ϭ 0.0224). The risk ratio of anti-HBc for shorter survival time was 3.817.

CONCLUSIONS.

HCC more often developed before cirrhosis in patients with HCV RNA and anti-HBc than in patients positive for HCV RNA alone. Prior HBV infection was a risk factor for poor outcome after liver resection for patients infected with HCV. [

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