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Production of 1-11C-acetoacetic acid

✍ Scribed by Maria G. Straatman; Alfred G. Hortmann; Michael J. Welch

Book ID: 102369405
Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 207 KB
Volume: 10
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590100121

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✦ Synopsis

Abstract

Interest in labeled compounds which can be studied as brain metabolites and can be detected in vivo has led to production of carbon‐11 labeled acetoacetic acid (1‐^11^C‐acetoacetic acid). This synthesis, which was designed specifically for use with short‐lived isotopes, utilizes a solution of the stable enolate anion of acetone, generated by the reaction of CH~3~Li and isopropenyl acetate, to which the ^11^CO~2~ is added to produce the labeled acetoacetic acid in ∼55% yield with a synthesis time of only 40 minutes from the end of bombardment.

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