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Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole Dihydrochloride

✍ Scribed by Anderson, Neal G.; Ary, Thomas D.; Berg, James L.; Bernot, Peter J.; Chan, Yeung Y.; Chen, Chien-Kuang; Davies, Merrill L.; DiMarco, John D.; Dennis, Ronald D.; Deshpande, Rajan P.

Book ID
115448461
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
334 KB
Volume
1
Category
Article
ISSN
1083-6160

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## Abstract The title compound was prepared by the LiAlT~4~ reduction of 5‐fluoro‐3‐[3‐[4‐(5‐methoxy‐4‐pyrimidinyl)‐1‐piperazinyl]‐3‐oxopropyl]‐1H‐indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol f

3-(1H-Indol-3-yl)-4-(3,4,5-tri­methoxy­p
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The crystal structure of the title compound, C 21 H 18 N 2 O 5 , was determined in order to study the electrocyclic reactivity of 3,4diaryl-1H-pyrrole-2,5-dione derivatives. Intermolecular hydrogen bonds form sheets.