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Process Control and Optimization for Heterologous Protein Production by Methylotrophic Pichia pastoris

✍ Scribed by GAO, Minjie; SHI, Zhongping


Book ID
120614732
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
709 KB
Volume
21
Category
Article
ISSN
1004-9541

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## Abstract A predictive control algorithm coupled with a PI feedback controller has been satisfactorily implemented in the heterologous __Rhizopus oryzae__ lipase production by __Pichia pastoris__ methanol utilization slow (Mut^s^) phenotype. This control algorithm has allowed the study of the eff