Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries

✍ Scribed by Katherine A. Bakeev

• Publisher: Wiley-Blackwell
• Year: 2005
• Tongue: English
• Leaves: 470
• Edition: 1st
• Category: Library

✦ Synopsis

The use of real or near real time measurement of chemical production process parameters as the basis for achieving control or optimisation of a manufacturing process has wide application in the petrochemical, food and chemical industries. Process analytical chemistry (PAC), or process analytical technology (PAT) as it has recently been called, is now being deployed in the pharmaceutical industry, where it is seen as a technology that can help companies to improve their conformity with manufacturing compliance regulations. The objective of this book is to provide a starting point for implementing process analytical chemistry tools in process monitoring applications or as part of a total quality management system. Written from the perspective of the spectroscopist required to implant PAT tools in a process environment, attention is focussed on measurements that are made “in process” at-line or off-line, providing data on product during manufacture. With chapters covering the key spectroscopic tools, their applications in the pharmaceutical and chemical industries and basic chemometrics, the novice can quickly develop a sound understanding of the most practical technologies and applications. Implementation strategies are fully covered and address some of the critical issues that need to be tackled when setting up a PAT project – including choosing a project with a sound business justification in the first place.

✦ Table of Contents

fmatter......Page 1
ch1......Page 18
ch2......Page 30
ch3......Page 56
ch4......Page 108
ch5......Page 150
ch6......Page 187
ch7......Page 204
ch8......Page 243
ch9......Page 346
ch10......Page 379
ch11......Page 409
ch12......Page 441
index......Page 462
ins1......Page 469