Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries, Second Edition

• Year: 2010
• Tongue: English
• Leaves: 570
• Category: Library

✦ Synopsis

Process Analytical Technology explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added.

Coverage includes:

• Implementation of Process Analytical Technologies
• UV-Visible Spectroscopy for On-line Analysis
• Infrared Spectroscopy for Process Analytical Applications
• Process Raman Spectroscopy
• Process NMR Spectrscopy: Technology and On-line Applications
• Fluorescent Sensing and Process Analytical Applications
• Chemometrics in Process Analytical Technology (PAT)
• On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry
• Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing
• NIR Chemical Imaging

This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT.

It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT.

Review from the First Edition

“The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology.”—Current Engineering PracticeContent:
Chapter 1 Overview of Process Analysis and PAT (pages 1–15): Jason E. Dickens
Chapter 2 Implementation of Process Analytical Technologies (pages 17–36): Robert Guenard and Gert Thurau
Chapter 3 Process Sampling: Theory of Sampling – the Missing Link in Process Analytical Technologies (PAT) (pages 37–80): Kim H. Esbensen and Peter Paasch?Mortensen
Chapter 4 UV?Visible Spectroscopy for On?Line Analysis (pages 81–106): Marcel A. Liauw, Lewis C. Baylor and Patrick E. O'Rourke
Chapter 5 Near?Infrared Spectroscopy for Process Analytical Technology: Theory, Technology and Implementation (pages 107–155): Michael B. Simpson
Chapter 6 Infrared Spectroscopy for Process Analytical Applications (pages 157–194): John P. Coates
Chapter 7 Raman Spectroscopy (pages 195–243): Nancy L. Jestel
Chapter 8 Near?Infrared Chemical Imaging for Product and Process Understanding (pages 245–279): E. Neil Lewis, Joseph W. Schoppelrei, Lisa Makein, Linda H. Kidder and Eunah Lee
Chapter 9 Acoustic Chemometric Monitoring of Industrial Production Processes (pages 281–302): Maths Halstensen and Kim H. Esbensen
Chapter 10 Process NMR Spectroscopy: Technology and On?Line Applications (pages 303–335): John C. Edwards and Paul J. Giammatteo
Chapter 11 Fluorescent Sensing and Process Analytical Applications (pages 337–352): Jason E. Dickens
Chapter 12 Chemometrics in Process Analytical Technology (PAT) (pages 353–438): Charles E. Miller
Chapter 13 On?Line PAT Applications of Spectroscopy in the Pharmaceutical Industry (pages 439–461): Brandye Smith?Goettler
Chapter 14 NIR spectroscopy in Pharmaceutical Analysis: Off?line and At?line PAT Applications (pages 463–491): Marcelo Blanco Romia and Manel Alcala Bernardez
Chapter 15 Near?Infrared Spectroscopy (NIR) as a PAT Tool in the Chemical Industry: Added Value and Implementation Challenges (pages 493–520): Ann M. Brearley and Susan J. Foulk
Chapter 16 Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing (pages 521–543): Katherine A. Bakeev and Jose C. Menezes