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Probabilistic Enrichment of Phosphopeptides by Their Mass Defect

✍ Scribed by Bruce, Can; Shifman, Mark A.; Miller, Perry; Gulcicek, Erol E.

Book ID
126405618
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
374 KB
Volume
78
Category
Article
ISSN
0003-2700

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## Abstract Mass spectrometry is the tool of choice to investigate protein phosphorylation, which plays a vital role in cell regulation and diseases such as cancer. However, low abundances of phosphopeptides and low degrees of phosphorylation typically necessitate isolation and concentration of pho