To attempt to understand the physical principles underlying protein crystallization, an algorithm is described for simulating the crystal nucleation event computationally. The validity of the approach is supported by its ability to reproduce closely the wellknown preference of proteins for particula
Probabilistic approach to protein crystal nucleation
β Scribed by Christo N. Nanev; Ivaylo Dimitrov
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 185 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0232-1300
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β¦ Synopsis
Abstract
Simple probabilistic model for stepβwise growth of polymers is used for making some parallels with the nucleation of protein crystals. Although the considerations are made within 1D case, this approximation still shows some important peculiarities of protein crystal nucleation and growth. Thus, the present approach turns out to be useful for interpretation of some important experimental results regarding these processes. (Β© 2007 WILEYβVCH Verlag GmbH & Co. KGaA, Weinheim)
π SIMILAR VOLUMES
## Abstract Using __meanβseparationβworks__ method of Stranski and Kaischew calculations of nucleus form and energy barrier for its formation are performed for globular protein crystals. This is done on the basis of a simple model suggested for crystal nucleation of such proteins. The prerequisite