Application of mean-separation-works method to protein crystal nucleation

✍ Scribed by Christo N. Nanev

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 142 KB
• Volume: 43
• Category: Article
• ISSN: 0232-1300
• DOI: 10.1002/crat.200711085

✦ Synopsis

Abstract

Using mean‐separation‐works method of Stranski and Kaischew calculations of nucleus form and energy barrier for its formation are performed for globular protein crystals. This is done on the basis of a simple model suggested for crystal nucleation of such proteins. The prerequisite for the model is the fact that strict selection of definite sticky patches on protein molecule surface is obligatory for forming crystal lattices. The calculation results are in agreement with experimental data. (© 2008 WILEY ‐VCH Verlag GmbH & Co. KGaA, Weinheim)