Primary allenic alcohols of high optical purity via lipase catalyzed resolution
β Scribed by Antonio Cipiciani; Francesca Bellezza
- Book ID
- 114395753
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 75 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1381-1177
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π SIMILAR VOLUMES
2-Cyano-2-phenyl-I-hexanol containing chiral quatemary carbon was resolved using a lipase. Among various reaction conditions, transesterification reaction (solvent; n-hexane, lipase; Candida cylindracea) gave high selectivity(20/80). Additionally, the selectivity could be improved( 13187) when pyrid
## Abstract Both enantiomers of the six major kinds of __Ξ³__βlactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__β__N__βmethylβ4βhydroxyalkanamides via Grignard reaction and the enantioselective acetylatio