𝔖 Bobbio Scriptorium
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Primary allenic alcohols of high optical purity via lipase catalyzed resolution

✍ Scribed by Antonio Cipiciani; Francesca Bellezza


Book ID
114395753
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
75 KB
Volume
17
Category
Article
ISSN
1381-1177

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## Abstract Both enantiomers of the six major kinds of __Ξ³__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio