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Preventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on DEN-induced hepatocarcinogenesis in rats

✍ Scribed by Takakazu Nagahara; Jun-ichi Okano; Yuki Fujise; Ryo Abe; Yoshikazu Murawaki

Book ID
116314263
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
623 KB
Volume
64
Category
Article
ISSN
0753-3322

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## Abstract We have previously demonstrated that JTE‐522, a selective cyclooxygenase‐2 (COX‐2) inhibitor, inhibited development of aberrant crypt foci (ACF) in rats, a putative preneoplastic lesion in colon, and suggested its inhibitory potential in rat colon carcinogenesis. To evaluate the chemopr