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Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis

✍ Scribed by Min Wei; Keiichirou Morimura; Hideki Wanibuchi; Jun Shen; Kenichiro Doi; Makoto Mitsuhashi; Masaharu Moku; Elsayed I Salim; Shoji Fukushima

Book ID
117467963
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
118 KB
Volume
202
Category
Article
ISSN
0304-3835

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JTE-522, a selective cyclooxygenase-2 in
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats
✍ Min Wei; Keiichirou Morimura; Hideki Wanibuchi; Jun Shen; Elsayed I. Salim; Masa πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 75 KB

## Abstract We have previously demonstrated that JTE‐522, a selective cyclooxygenase‐2 (COX‐2) inhibitor, inhibited development of aberrant crypt foci (ACF) in rats, a putative preneoplastic lesion in colon, and suggested its inhibitory potential in rat colon carcinogenesis. To evaluate the chemopr