Prevention of HIV coat protein (gp120) toxicity in cortical cell cultures by riluzole
β Scribed by P. Sindou; P. Couratier; F. Esclaire; C. Yardin; A. Bousseau; J. Hugon
- Book ID
- 118932115
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 603 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0022-510X
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π SIMILAR VOLUMES
PKC) translocation to the plasma membrane], we studied the effect of gp120 and glutamate on the binding of 4f3-[3H]phorbol-12,13-dibutyrate, a specific ligand for membrane PKC. While glutamate caused a dose-dependent, APV-sensitive increase in binding, gp120 determined a decrease in basal binding, s
HIV-l-associated cognitive/motor complex is one of the major neurological complications of AIDS and is associated with neuronal loss. Gp120, the HIV envelope protein, is toxic for neurons in cultures and produces a rise in intracytosolic calcium. This neurotoxicity is dose-dependent and time-depende