Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures

✍ Scribed by T. Savio; Dr. G. Levi

• Book ID: 102908511
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 830 KB
• Volume: 34
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490340303

✦ Synopsis

PKC) translocation to the plasma membrane], we studied the effect of gp120 and glutamate on the binding of 4f3-[3H]phorbol-12,13-dibutyrate, a specific ligand for membrane PKC. While glutamate caused a dose-dependent, APV-sensitive increase in binding, gp120 determined a decrease in basal binding, suggesting that its mechanism of action does not involve PKC translocation.