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Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase

✍ Scribed by M.T Corasaniti; G Melino; M Navarra; E Garaci; A Finazzi-Agrò; G Nistico

Book ID: 116173616
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 613 KB
Volume: 4
Category: Article
ISSN: 1055-8330
DOI: 10.1016/1055-8330(95)90021-7

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## Abstract Nitric oxide (NO) is cytotoxic for human SH‐SY5Y neuroblastoma cells. While nuclear condensation was visible in cells treated with nitric oxide donors, we observed that the plasma membrane remained intact, indicating that NO induced apoptotic cell death. We analyzed the NO‐induced apopt